危重病患者全胃肠外营养的临床研究

Clinic Research of Total Parenteral Nutrition in Critically III Patients

目的:探讨危重病患者急性期全胃肠外营养(TPN)治疗的意义。方法:采集外周静脉血测定血浆纤维蛋白原、白蛋白、总胆固醇、甘油三脂、淋巴细胞计数,分析两组医院感染率、病死率及呼吸机辅助呼吸时问。结果:危重病患者急性期血浆纤维蛋白原、白蛋白、总胆固醇、甘油三脂、淋巴细胞计数在两组均无显著差异,P>0.05。TPN治疗组呼吸机通气时间显著短于非TPN治疗组,P<0.05。两组医院感染率、病死率无显著差异,P>0.05。结论:营养评价指标血浆纤维蛋白原、白蛋白、总胆固醇、甘油三脂、淋巴细胞计数对危重病患者急性期无评价作用。TPN治疗可缩短呼吸机辅助通气时间,且不会增加医院感染率。

Objective: To determine effect of total parenteral nutrition (TPN)treatment on critically ill patients. Methods: Plasma fibrinogen, albumin, cholesterol, glycerin, blood lymphocytes are assayed in critically ill patients. Hospital acquired infection rate, mortality and assisted mechanical ventilator time are also analysed. Results: Plasma fibrinogen,albumin,cholesterol,glycerin,blood lymphocytes are insigniiicandy changed in acute critically ill patients,P> 0.05. Patients need less assisted mechanical ventilator time than non-TPN group after TPN treatment. Hospital acquired infection rate and mortality are insignificantly difference between TPN group and non- TPN group,P > 0.05. Conclusion: Plasma fibrinogen, albumin, cholesterol, glycerin, blood lymphocytes have no value for assessing nutrition condition in acute critically ill patients,but patients need less ventilator assistant time after TPN treatment,meanwhile,hospital acquired infection rate of patients is not increase.