微剂量异丙酚对术后恶心呕吐的作用

Effect of Micro-dose Propofol on Postoperative Nausea and Vomitting

目的:异丙酚为镇静催眠药物,有研究表明其可能具有治疗术后恶心呕吐的作用。本研究通过对60例择期腹部肿瘤手术患者的观察,了解其对术后恶心呕吐的作用。方法:60例ASAI-Ⅱ择期腹部肿瘤手术患者,随机分为实验组和对照组,实验组在麻醉苏醒后静脉注入异丙酚0.2 mg/kg,对照组使用生理盐水2 mL。观察麻醉苏醒后6h内两组患者恶心呕吐的发生率以及镇静/清醒评分。结果:实验组在麻醉清醒后6 h内恶心发生率(16.6％)明显低于对照组(26.6％),P<0.05,但是呕吐发生率没有差异。结论:微剂量的异丙酚用于直接治疗术后恶心呕吐有一定的疗效,但是具体临床使用剂量以及时机尚需要进一步的研究。

Objective: Propofol is a sedative and hypnotic drug. Current studies demonstrated that propofol could have effective of depressing the postoperative nausea and vomiting(PONV). 60 ASA I - II patients underwent abdominal tumor surgery were involved in this study, and the effect of micro-dose propofol on PONV was observed. Methods: 60 ASA grade I - II patients were randomly divided into 2 groups. Propofol group and control group. 0.2 mg/kg propofol was administrated intravenous when the patient was awake from anesthesia, as to the control group, 2 mL saline was administrated as placebo. PONV and OAA/S was recorded in the 6 hrs after surgery. Results: Nausea in the propofol group was 16.6% in 6Hrs, it was significantly lower than the control group (26.6%),P<0.05, but there're no statically difference on vomiting in 6Hrs between the two group. Conclusion: Micro-dose propofol did depress the PONV, but further studies are demanded.