静脉应用乌拉地尔治疗高血压危象76例临床观察

The Clinical Observation of Urapidil Used Intravenous in Patients with Hypertensive Crisis

目的:观察乌拉地尔治疗高血压危象的临床疗效。方法:76例高血压危象患者予乌拉地尔首剂25 mg加入生理盐水10 mL中缓慢静脉推注,随后以50 mg加入葡萄糖或生理盐水250 mL中缓慢静滴,初始速度为15 mg/h,根据血压调整滴速,至血压为160-170/100-110 mmHg后维持12 h。治疗过程中予持续心电监护和血压监测,在治疗后前半小时每5分钟一次、以后每小时记录一次血压、心率的变化,持续12 h,并观察不良反应。结果:治疗后收缩压、舒张压较治疗前均有显著下降(P<0.01),心率改变不明显(P>0.05);总有效率为95.6％,起效时间为(5.2±1.8)分钟,症状改善时间为(34.6±9.8)分钟:且无严重不良反应。结论:乌拉地尔静脉应用治疗高血压危象起效快,降压平稳,安全性高。

Objective: To observe the clinical efficacy of Urapidil in patients with hypertensive crisis. Methods: 76 cases suffered hypertensive crisis were treated with first intravenous injection Urapidil at the dosage of 25 mg together with 10 mL sodium chloride, which was followed by continual intravenous Urapidil at the velocity of 15 mg/h that was adjusted promptly according to the patients' blood pressure(BP), till an optimal BP(160-170/100-110 mmHg). Then, keep the optimal dosage 12 hours. Both of BP and heart rate were monitorred. The changes of BP,heart rate and side effects were recorded at every 5 min in the first 30 mins and each 1 h in 1 h-12 h after the treatment. Results: BP was significantly reduced but no changes in heart rate were observed. The total effective rate, effective time were 93.37%, (5.2±1.8)min, the optimal time was (34.6±9.8)min and no obvious side effects were observed. Conclusion: Urapidil is effective and safe in treatment of hypertensive crisis.