宫颈宫内膜样型微小偏离性腺癌报道及文献复习

Minimal deviation endometrioid adenocarcinoma of the cervix-a case report and review

目的:探讨宫内膜样型微小偏离性腺癌的临床、病理特点及鉴别诊断。方法:报道一例宫内膜样型微小偏离性腺癌临床及病理特点,并复习文献探讨其诊断及鉴别诊断。结果:宫内膜样型微小偏离性腺癌主要临床表现为水样白带,宫颈肥大伴糜烂;镜下为类似良性增生的宫内膜样腺体浸润宫颈壁深层,无间质反应;免疫组化标记:CEA(+),PCNA(+),53(+),ER(-),PR(-),C-erbB-2(-)。结论:宫内膜样型微小偏离性腺癌是宫颈罕见肿瘤,临床病史及免疫组化标记在诊断及鉴别诊断中具有重要作用。

Objective To investigate clinical and pathological characters of minimal deviation endometrioid adenocarcinoma(MDEA) and its differential diagnosis. Methods A case of minimal deviation endometrioid adenocarcinoma was reported with clinical and pathological findings, and discussed in differential diagnosis with review of the literature. Results The main clinical symptoms were watery leucorrhagia, enlargement of the cervix with erosion. Microscopic examination disclosed a deceptively benign- appearing proliferation of endometrial- type glands infiltrating the cervical wall without a stromal response. Compared with benign glands, the immunohistochemistry markers were demonstrated as CEA+ , PCNA+ + , P53+ , ER- , PR- .Conclusion MDEA is a rare tumor of the cervix. The clinical history and immunohistochemistry markers play an important role in diagnosis and differential diagnosis.