细胞因子对血吸虫病肝纤维化形成的影响(综述)

The effect of cellular factors on hepatic fibrosis of schistosomiasis japonica

目的:探讨细胞因子对血吸虫病肝纤维化形成的影响。方法:查阅近10年国内外相关文献,并对文献进行分析、综述。结果:肝纤维化是血吸虫病的一个重要病理改变,细胞因子在血吸虫病性肝纤维化的发生发展过程中起着重作用,其中促肝纤维化的细胞因子是转化生长因子β1(TGF-β1)、血小板衍生生长因子(PDGF)、肿瘤坏死因子-α(TNF-α)、白介素(IL-1、IL-2、IL-4、IL-5、IL-6、IL-8、IL-13)、碱性成纤维细胞生长因子(bFGF)等,抗肝纤维化细胞因子是干扰素-γ(IFN-γ)、IL-10、IL-12、IL-18等。结论:深入研究细胞因子在肝纤维化形成机制中的作用有重要意义。

Objective To probe into the effect of cellular factors on hepatic fibrosis of schistosomiasis japonica.Methods To cousult the related domestic and foreign articles of last ten years for analyzing and summarizing. Results Hepatic fibrosis is one of the most important pathological feature in schistosomiasis japonica,and during the course of hepatic fibrosis in schistosomiasis japonica the cellular factors play major roles. Among the cellular factors ,some drive the hepatic fibrosis in schistosomiasis japonica,such as transforming growth factor- β 1,platelet- derived growth factor,tumor necrosis factor- α ,interleulin- 1, interleulin- 2,interleulin- 4,interleulin- 5,interleulin- 6,interleulin- 8,interleulin- 13, basic fibroblast growth factor and so on;some inhibit the hepatic fibrosis in schistosomiasis japonica,such as interferon- γ , interleulin- 10, interleulin- 12, interleulin- 18 and so on.Conclusion It is important to go on with further study on the effect of cellular factors on hepatic fibrosis of schistosomiasis japonica.