轻中度高血压合并早期肾损害脉压、脉压指数检测及意义

The significance of the pulse pressure(PP) and the pulse pressure index(PPI) in the patients with early renal injury with hypertension

目的 探讨轻中度高血压患者早期肾损害与脉压、脉压指数的关系。方法 10 0例轻中度高血压患者检测血、尿β2 MG及尿白蛋白同时计算脉压、脉压指数 ,根据有无肾损分组检测脉压、脉压指数差异 ;根据脉压、脉压指数分组检测血、尿β2 MG及尿白蛋白。结果 PP >6 0mmHg的高血压患者血 β2 MG (4 2 4± 1 18)mg/L ,尿 β2 MG (1 17±0 88)mg/L ,尿白蛋白 (2 4 8± 7 3)mg/L ;PP <6 0mmHg的高血压患者血 β2 MG(2 5 6± 1 34)mg/L ,尿 β2 MG(0 4 2±0 10 )mg/L ,尿白蛋白 (18 3± 4 7)mg/L ;PPI >0 6的高血压患者血 β2 MG (4 5 6± 1 2 3)mg/L ,尿 β2 MG (1 0 9±0 5 6 )mg/L ,尿白蛋白 (2 5 3± 4 5 )mg/L ;PPI <0 6的高血压患者血β2 MG(2 4 9± 1 0 9)mg/L ,尿 β2 MG(0 33± 0 0 9)mg/L ,尿白蛋白 (17 4± 3 3)mg/L。结论 高血压合并早期肾损害患者脉压、脉压指数明显升高。

Objectives To evaluate the relationship between the early renal injury in hypertension patients and the pulse pressure and the pulse pressure index. Methods To calculation the pulse pressure(PP) and the pulse pressure index(PPI) in 100 patients with mild to moderate essential hypertension and to detect the serum β 2-microglobulin(β 2-MG)and the urine β 2-microglobulin(β 2-MG)?albumin. Results The serum β 2-microglobulin(β 2-MG) and the urine β 2-microglobulin(β 2-MG), albumin in patients with whose pulse pressure was >60mmHg were higher than whose pulse pressure was <60mmHg. The serum β 2-microglobulin(β 2-MG) and the urine β 2-microglobulin(β 2-MG),albumin in patients with whose pulse pressure index was >0.6 were higher than whose pulse pressure index was <0.6. Conclusions Pulse pressure and pulse pressure index is higher in the patients with hypertension and early renal injury.