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血清CK-MM亚带MM_3/MM_1比值与CK-MB和Mb测定早期诊断急性心肌梗塞的比较

Comparison of Serum CK-MM Isoform MM_3/MM_1 Ratio and CK-MB and Mb Determination in Early Diagnosis of AMI
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摘要 本文采用琼脂凝胶电泳法测定62例急性心肌梗塞(AMI)和19例心绞痛(AP)病人血清肌酸激酶MM同功酶(CK-MM)亚带MM_3/MM_1比值及肌酸激酶同功酶(CK-MB)和肌红蛋白(Mb)的改变,并比较它们在AMI中的诊断价值。结果表明:AMI组首次血清的MM_3/MM_1比值为1.85±2.01(x±s),AP组为0.24±0.14,二者比较差异非常显著(P<0.01)。首次血清和系列测定对AMI的早期诊断价值高于CK-MB和Mb。本组结果亦表明MM_3/MM_1比值的累积阳性率于梗塞发生后6小时达100%。提示血清CK-MM亚带MM_3/MM_1比值异常是AMI早期诊断中敏感而特异的酶学诊断指示。 In this study we quantified changes of serum CK-MM isoforms (MM_3/MM_1 ratio)from 81 consecutive coronarycare admission, Of these, 62 patients were diagnosed asdefinite infarction and 19 patients as angina, with WHO criteria. The MM_3/MM_1ratio in the admission serum sample was 1.85+/-2.01 in 62 patients with infarc-tion; in contrast, it was 0.24+/-0.14 in 19 patients with angina (P<0.01). Thediagnostic value of the ratio MM_3/MM_1 was better than CK-MB and Mb in the ini-tial serum sample and the serial monitored ones. Accordingly, the MM_3/MM_1 ratiowas a sensitive and specific indicator of AMI.
出处 《天津医药》 CAS 1992年第1期6-10,共5页 Tianjin Medical Journal
关键词 肌酸激酶 肌红蛋白 心肌梗塞 creatine kinase creatine kinase isoenzyme myoglobin myocardial infarction
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  • 1孟庆义,杨兴生.血清肌酸激酶MM同功酶亚带琼脂凝胶电泳方法的建立[J]解放军医学杂志,1990(06).
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