摘要
采用随机开放试验,区组随机分组、应用环丙氟哌酸对10对呼吸道感染,4对急性软组织化脓性感染及11对肾盂肾炎试验组病人进行了前瞻性对照研究。前二组对照药用头孢氨苄、第三组用氟哌酸。结果证实,口服环丙氟哌酸具有抗菌谱广,抗菌作用强的特点,优于氟哌酸及常用的头孢菌素。体外细菌敏感试验提示,对头孢菌素、氟哌酸及其它常用抗生素耐药的革兰氏阴性及阳性菌对本品仍敏感,不易产生耐药性。环丙氟哌酸副作用少,偶见胃肠反应及药疹可自行消退,适用于临床多细菌感染性疾病。
Ten pairs of cases of respiratory tract infection, 4 pairs of cases of soft tissuepyogenic infection and 11 pairs of cases of urinary tract infection were studed. Theywere randomly allocated to one of the two treatment subgroups for determiningantibiotic activity of ciprofloxacin in trial subgroups of the three disease groups.Cephalexin was used in the control subgroups of respiratory tract infection andsoft tissue pyogenic infection and Norfloxacin was used in the control subgroupsof urinary tract infection. The result demonstrated that Ciprofloxacin was abroadspectrum antibiotical agent more effective than Norfloxacin and cephalexin. In vitrobacterial sensitivity test suggested that ciprofloxacin was an effective antibioticagent against gram-negative and positive pathogens that were resistant to Norfloxacin,Cephalexin and other antibiotics. Most of the side-effects of Ciprofloxacin snch asgastrointestinal disturbances and allergic rash reaction were mild and disappearedspontaneously. It was concluded that Ciprofloxacin was effective in treating generalmicrobial infection due to most gram-negative and positive pathogens.
出处
《天津医药》
CAS
1992年第2期97-100,共4页
Tianjin Medical Journal
关键词
氟哌酸
呼吸道感染
泌尿系统感染
Ciprofloxacin
acute respiratory tract infection
urinary tract
infection
acute pyogenic infection of soft tissue