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LAT与HSV-1的潜伏感染及再激活 被引量：2

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摘要 单纯疱疹病毒性脑炎的发病大多数是由潜伏的单纯疱疾病毒再激活引起已基本得到公认,但病毒潜伏及再激活的具体机制还不十分明确,本文就国外近年来LAT在单纯疱疹病毒潜伏感染的建立、维持和再激活过程中所起的重要作用作一简要综述。
作者 赵高年 李勇 谢鹏
机构地区 重庆医科大学附一院神经科
出处 《中国临床神经科学》 2003年第4期425-428,共4页 Chinese Journal of Clinical Neurosciences
关键词 LAT HSV-1 潜伏感染 再激活 单纯疱疹病毒性脑炎 基因结构
分类号 R512.3 [医药卫生—内科学]
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参考文献21

  • 1Gerber DA, Schaffer PA, Knipe DM. A LAT-associated functio reduces porductive-cycle gene expression during acute infection of murine sensory neurons with herpes simplex vires type 1 [J] .J Virol, 1997,71:5885-5893.
  • 2Mador N, Goldeuberg D, Cohen O, et al. Herpes simplex virus type 1 latency-associated transcripts suppress viral replication and reduce immediate-eady gene mRNA levels in a neuronal cell line [J]. J Virol,198,72:5067-5075.
  • 3Peang C,C, Ghiasi H, Slanina SM, et al. The spontaneous reactivation function of the herpes simplex vires type 1 LAT gene resides completely within the first 1.5 kilohase d the 8.3 kilohase primary transcript[J]. J Virol, 1996,70: 976-984.
  • 4Perng GC, Jones C, Ciacci-Zanella J, et al. Virus-induced neuronal apoptosis blocked by the herpes simplex vires latency-associated transcript[ J ]. Science, 2000,287:1500-1503.
  • 5Thompson RL,Sawteell NM. Herpes sirraplex virus type 1 latency-assoclated transcript gene promotes survival[ J ].J Virol, 2001,75: 6660-6675.
  • 6Perng GC, Magten B,Jin L,et al.A gene capable of blocking apoptosis can substitute for the herpes simplex vires type Ⅰ latency-associated transcript gene and restore wild-type reactivation levels[ J ]. J Virol, 2002,76: 1224-1235.
  • 7Ahmed M, Imck M, Cathie G, et al. Regions of the herpes simplex vires type 1 latency-associated transcript that protect cells form apoptosis in vitro and protect neuronal cells in vivo[]].] Virol,2002,76:717-729.
  • 8Henderson G,Peng W,Jin L, et al. Regulation of caspase-8 and caspase-9 induced apoptosis by the herpes simplex virus type 1 latency-associated transcript[J].J Neurovirol,2002, 2 : 103-111.
  • 9Thomas SK, Gough G, Latchrnan DS, et al. Herpes simplex vires latency-associated transeript encodes a protein which treatly enhances vires growth,can compensate for deficiencies in immediate-gene expression, and is likely to function during reactivation from vires latenct [ J ]. J Virol, 1999, 73:6618-6625.
  • 10Thonms SK, Lilley CE, Latchman DS, et al. A protein encoded by the herpes simplex virus (HSV)type 1 2-kilobase lateucy-associated transcript is phosphorylated, localized to the nucleus, and overcomes the repression of expression from exogenous promoters when inserted into the quiescent HSV genome[J]. J Virol,2002,76:4056-4067.

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中国临床神经科学
2003年 第4期

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