COPD和肺心病急性期患者肾素—血管紧张素—醛固酮系统的变化

Renin-Angiotensin II-Aldosterone System Changes at Acute Stage of COPD and Cor Pulmonale

对86例慢阻肺和肺心病急性期患者用放射免疫分析法测定血浆肾素活性、血管紧张素Ⅱ、醛固酮及促肾上腺皮质激素含量。发现患者上述各项指标均较正常人明显升高(P<0.01);同时还发现严重低氧血症和伴高碳酸血症者(PaO_2平均5.33kPa、PaCO_2平均9.46kPa)肾素活性、血管紧张素Ⅱ、醛固酮的含量上升则相当显著,提示肾素-血管紧张素-醛固酮系统的活性与PaO_2、PaCO_2密切相关。

PRA, AT_(Ⅱ) and Ald levels in plasma were determined in 86 patients with COPD and chronic cor pulmonale during the acute stage with radioimmunoassay. It was found that all parameters were apparently higher than those in normal control (P<0.01), and PRA, AT_(Ⅱ). Ald also increased greatly in patients with severe hypoxemia and hypercarboxemia (mean value PaO_2 5.33 kPa, PaCO_2 9.46kPa). It was suggested that there was significant relation between PaO_2, PaCO_2 and activities of PRA, AT_(Ⅱ) and Ald in the plasma.