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乳癌组织p73基因的分析 被引量：1

Analysis of p73 gene in breast cancer
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摘要 目的 :研究p73基因与乳癌的关系。方法 :应用免疫组化、RT PCR等技术检测乳癌组织p73基因的表达情况。结果 :45例乳癌组织p73基因表达阳性者 2 1例 ,明显高于良性乳腺肿瘤 (P <0 .0 5) ;淋巴结转移阳性者p73基因表达明显高于阴性者 (P <0 .0 5)。结论 Objective:To investigate the relationship between p73 gene and breast cancer.Methods:The expression of p73 gene in breast cancer tissues wer e detected by immunohistochemical and RT-PCR. Results:The expression of p73 gene is significantly higher in b reast cancer(21/45) than in breast benign tumors(P<0.05);also i s significantly higher in positive metastasis of lymph nodes than in nagetive o nes(P<0.05). Conclusion:The increasing expression of p73 gene may be related with breast cancer.
作者 杨开颜
机构地区 温州医学院第一附属医院病理科
出处 《温州医学院学报》 CAS 2003年第6期369-370,373,共3页 Journal of Wenzhou Medical College
基金 温州市科技发展计划基金资助项目 (S2 0 0 1A2 9)
关键词 P73 腺癌 免疫组化 RT-PCR p73 breast cancer immunohischemical RT-PCR
分类号 R737.9 [医药卫生—肿瘤]
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二级参考文献18

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共引文献3

同被引文献4

  • 1杨万广,刘保池,王钟富.p63,p73蛋白在乳腺癌组织中的表达及其意义[J].中国误诊学杂志,2007,7(14):3194-3195. 被引量：2
  • 2Gemma Dominguez,Jose M. Silva,Javier Silva,Jose M. Garcia,Antonio Sanchez,Antonia Navarro,Isabel Gallego,Mariano Provencio,Pilar Espa?a,Felix Bonilla. Wild Type p73 Overexpression and High-Grade Malignancy in Breast Cancer[J] 2001,Breast Cancer Research and Treatment(3):183～190
  • 3David I. Schwartz,Noralane M. Lindor,Cate Walsh-Vockley,Patrick C. Roche,Ming Mai,David I. Smith,Wanguo Liu,Fergus J. Couch. p73 mutations are not detected in sporadic and hereditary breast cancer[J] 1999,Breast Cancer Research and Treatment(1):25～29
  • 4杨万广.Survivin和p73在乳腺癌组织中的表达及意义[J].医药论坛杂志,2008,29(10):43-44. 被引量：1

引证文献1

温州医学院学报
2003年 第6期

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