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γ-氨基丁酸和脑缺血 被引量:6

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摘要 γ-氨基丁酸(GABA)作为中枢神经系统内的最重要的抑制性神经递质,在脑缺血诱发的神经元死亡中的作用开始受到重视,GABA能药物在许多动物脑缺血模型中均显示良好的神经保护作用[1].本文重点在于阐述GABA神经传递在脑缺血诱发的神经元死亡中的作用,并提供缺血诱发的神经元死亡与GABA神经传递改变之间的关系以及GABA能药物对神经细胞保护作用的证据.
出处 《卒中与神经疾病》 2003年第6期373-375,共3页 Stroke and Nervous Diseases
基金 国家自然科学基金 (No.30200083) 湖北省科技攻关计划(No.2002AA304B309)
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  • 1[1]Sommner C, Fahrner A, Kiessling M, et al.Postischemic neuroprotection in the ischmiatolerant state gergbil hippocampus in associated with increased ligand binding to in hibitory GABA (A) receptors. Acta Neuropathol (Berl) ,2003,105: 197
  • 2[2]Schwartz RD, Yu X, Katzman MR, et al.Diazepam, given post-ischemia, protects selectively vulnerable neurons in rat striatum and hippocampus. J Neurosci, 1995,15: 529
  • 3[3]San R, Schwartz-Bloom RD. Optical imaging reveals elevated intracellular chloried in hippocampal pvramidal neurons after oxidative stress. J Neurosci, 1999, 19: 9209
  • 4[4]Centonze D, Saulle E, Pisani A, et al.Adenosine-mediated inhibition of striatal GABAergic synaptic transmission during in vitro ischmia. Brain 2001,124:1855
  • 5[5]Arabadzisz D, Freund TF. Changes in excitatory and inhibitory circrits of hte rat hippocampus 12-14 months after complete forebrain ischemia. Neuroscience, 1999,92: 27
  • 6[6]Alicke B, Schwartz-Bloom RD. Rapid downregulation of GABA (A) receptors in gerbil hippocanpus following cerebral ischmia. J Neurochem, 1995,65: 2808
  • 7[7]Inglefield JR. Schwartz-Bloom RD. Optical imaging of hippocampal neurons with a chloride-sensitive dye: early effects of in vitro ischemia. J Neurochem, 1998,70: 2500
  • 8[8]Sah R. Schwartz-Bloom RD. Optical imaging reveals decreased GABA(A) responses in adult hippocarmpal neurons following in vitro ischemia and oxidative stress. Soc. Neurosci.Abstract. 2000,26: 2068
  • 9[9]Kaila K, Ionic basis of GABA(A) receptor channel function in the nervous system. Prog Neurobiol, 1994,42: 489
  • 10[10]Leinekugel X, Khalilov I, McLeanH, et al.GABA is the principal fast-acting excitatory transmitter in the meonatal brain. Adv Neurol, 1999,79:189

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