摘要
本文报道国产甲氟哌酸片剂的人体药代动力学研究结果。血、尿药物浓度用微生物打孔法测定。健康志愿者口服甲氟哌酸400mg片剂后,体内药物转运过程符合一室开放模型。甲氟哌酸的血药浓度达峰时间、峰浓度为1.27小时和4.76μg/ml。T_(1/2)Ka和T_(1/2)Ke分别为0.22和10.40小时。研究结果表明,甲氟哌酸吸收快,达峰迅速,血清峰浓度有所提高,消除半衰期长,体内分布广泛,值得在临床推广使用。
Clinical pharmacokinetic study of pefloxacin was carried on. The drug concentra-tion was measured by bioassay method. Ten normal volunteers were given a singledose of 400mg of the drug by p.o. adminstration. The serum drug level-time profileof pefloxacin was conformed to the one compartment open model. After oral admini-stration of 400mg pefloxacin, T (Peak), C (max), T1/2ka, T1/2ke were 1.27h, 4.76μg/ml,0.22 and 10.40 hour, respectively. The result indicated that pefloxacin might proveuseful in the treatment of various infections in human beings.
出处
《天津医药》
CAS
1992年第6期353-355,共3页
Tianjin Medical Journal
关键词
甲氟哌酸
药代动力学
微生物法
人
pefloxacin
pharmacokinetics
microbiologic method
human
