胚胎肾上腺移植治疗慢性支气管哮喘的临床研究

Clinical Study on Embryonic Adrenal Graft in Treatment of Chronic Bronchoasthma

本文报道1989年5月～1990年5月间,我们采用胚胎肾上腺移植治疗76例慢性支气管哮喘患者,移植后随访一年以上。结果:临床治愈4例(5.2％),显效15例(19.8％),有效36例(47.4％),总有效率72.4％。患者多感体力增加,感冒减少,肺通气功能FVC、FEV_1、FEV_1％、PEFR较移植前有明显改善(P<0.01),血浆皮质醇上升(P<0.05);血压、体重、血糖及血钾、钠、氯均无明显变化(P>0.05)。此种移植手术操作简便,能重复进行,对中老年慢性难治性哮喘或激素依赖型患者,可作为一种治疗手段。

With the method of embryo adrenal gland grafting 76 patients with chronic bron-chial asthma were treated from May 1989 to May 1990. A follow-up over one yearafter grafting showed that 4 cases were cured (5.2%), 15 were markedly improved(19.8.%) and 36 cases were improved (47.4%), the overall improvement rate being72.4%. Most of the patients felt strenthened and less susceptible to common cold.Lung ventilation function FVC FEV_1 PEFR had marked improvement (P<0.01). Thecortisone concentration in plasma increased (P<0.05), BP, BW, blood sugar and bloodpotassium. sodium and chlorine remained unchanged (P>0.05). This mathod of graf-ting is simple and it can be done repeatedly on middle and old aged patients withchronic refractory asthma or corticosteroid dependent patients, and hence is worthwhile to be recommended.