摘要
原发性肝癌(PHC)发病呈明显的家族聚集性,为进一步了解PHC的聚集规律和特征,探讨亲代遗传效应,本文分析了290个PHC家族的资料。结果表明:在肝癌家族史中,以母患肝癌为多见;尤其肝癌高发家族中45.28％先证者的母亲曾患肝癌,而且表明伴HBV感染的母患肝癌的先证者显著多于不伴HBV感染者(P<0.05)。显示了母患肝癌对子代的遗传效应远大于父患肝癌对子代的影响。可以认为有母患肝癌家族史,尤其伴HBV感染的肝癌家族成员罹患肝癌的风险更大,应对其加强随访,警惕PHC的发生。
Two hundred and ninety families with primary liver cancer (PLC) were analysed,in order to understand the features of clustering in PLC families. The results showedthat the frequency of having PLC in the proband mothers was greater than in pointers'fathers, especially in the high risk families of PLC, which accounted for 45.28%.Moreover, HBV infection rate in proband whose mothers suffered from PLC was higherthan in proband whose fathers did, showing that maternal hereditation might be moreimportant. It was suggested that familial members with PLC history from theirmothers, especially with HBV infection, was associated with the increased risk of PLC,hence close follow up was essential.
出处
《天津医药》
CAS
1992年第12期717-719,共3页
Tianjin Medical Journal
关键词
原发性
遗传
肝肿瘤
家系
遗传性
primary liver cancer
liability
HBV infection
