大花红景天多元酚类化学成分的研究

STUDIES ON THE POLYPHENOL CONSTITUENTS OF RHODIOLA CRENULATA

从大花红景天Rhodiola crenulata (HK.f.et thoms)H.Ohba的乙酸乙酯提取物中分离出12个多元酚类化合物。其中六个经光谱分析和化学方法鉴定为没食子酸(gallic acid,1),酪醇(p-tyrosol,2),6-氧-没食子酰基红景天甙(6-O-galloylsalidroside,3),1,2,3,4,6-五氧-没食子酰基-β-D-吡喃葡萄糖(1,2,3,4,6-penta-O-galloyl-β-D-gluco pyranoside,4),草质素-7-氧-α-L-吡喃鼠李糖甙(rhodionin,5),草质素-7-氧-(3-氧-β-D-吡喃葡萄糖基)-α-L-吡喃鼠李糖甙(rhodiosin,6),1和4具有抗毒肝素的活性,4还有抗脂质过氧化的活性,2,5,6具有提高机体抗逆境能力的活性。

Twelve Polyphenol compounds were isolated from the AcOEt cxtract of Rhodiola crenulata (HK. f. et thorns) H. Ohba. By means of spectral analyses and chemical methods, six of them were determined to be gallic acid (1), P tyrosol (2), 6-O galloylsalidroside (3), 1, 2, 3, 4, 6-penta-O-galloyl β D glu-copyranoside (4), herbacetin-7-O-α-L-rhamnopyrano side (rhodionin, 5), herba-cetin-7-O-(3-O-β-D-glucopyranosyl-α L-rhamnopyranoside (rhodionin, 6). 2, 5, 6, have the activities to make the body strong and. improve the ability of the body to adaPt the adverse circumstances. 4 has strong inhibitory effect on lipid Peroxidation. 1, 4 have remarkable antihcpatotoxic activies.