轻舒颗粒治疗便秘(肾虚精亏证)的随机、阳性药平行对照临床试验

A Randomized Control Paralleled Clinical study on Constipation(Syndrome of Kidney Deficiency and Damage of Essence)Treated with Qingshu Granule

目的 :评价轻舒颗粒治疗便秘 (肾虚精亏证 )的疗效与安全性。方法 :随机、阳性药对照设计 ,将6 0例便秘患者随机分为治疗组 (n=30 )和对照组 (n =30 ) ,分别接受轻舒颗粒及麻仁丸治疗 ,观察治疗前后症状积分及舌脉变化。结果 :治疗组 30例 (轻舒颗粒 )总显效率 6 3 34% ,总有效率 96 6 7% ;对照组 (麻仁丸 )总显效率 4 6 6 7% ,总有效率 86 6 7%。治疗组与对照组比较无统计学意义 (P >0 0 5 ) ,但轻舒颗粒对改善患者症状 ,尤其对改善患者腰膝酸软症状明显优于麻仁丸。结论 :轻舒颗粒治疗便秘 (肾虚精亏证 )疗效确切 。

Objective:To evaluate the efficacy and safety of Qingshu Granule on constipation(syndrome of kidney deficiency and damage of essence).Methods:Sixty patients with constipation were randomly divide into two groups,and the treated group induded 30 patients treated with Qingshu granule and 30 the control group treated with Marne pills.The scores of syndromes and the change of condition of the tongue and pause condition before and after treatment were observed.Results:Clinical study showed that in the treated group,the markedly effective rate was 63.34%,and the total effective rate was 96.67%;while in the control group,the results were 46.67% and 86.67% respectively.The effecacy of the two groups was insignificant difference statistically(P>0.05).Conclusion:Qingshu granule was effective as a treatmeat for constipation(syndrome of kidney deficiency and damage of essence)and had no obvious side-effect.