摘要
目的 :探讨环磷酰胺、秋水仙碱联合应用对急性缺血性中风病人CD11a、CD11b、CD18和CD5 4的影响。方法 :84例发病 72小时内的脑梗死病人 ,随机分为处理组 (4 3例 )和对照组 (4 1)例。对照组接受急性脑梗死的基本治疗 ,处理组除接受对照组的治疗外 ,再加上环磷酰胺 0 1～ 0 2g/d静滴和秋水仙碱 1mg/d口服共 10天治疗。两组病人分别于治疗前后测CD11a、CD11b、CD18和CD5 4。结果 :处理组CD18在单核细胞、中性粒细胞上表达减少的百分率 ,以及CD5 4在单核细胞、中性粒细胞及淋巴细胞上表达减少的百分率与对照组相比 ,差异有显著性 (P <0 0 5 ) ;CD11a在单核细胞、中性粒细胞及淋巴细胞上表达减少的百分率 ,CD11b在单核细胞、中性粒细胞上表达减少的百分率两组无显著性差异 (P >0 0 5 )。结论 :环磷酰胺、秋水仙碱联合应用能减少急性缺血性中风病人白细胞上CD18、CD5 4的表达 ,对白细胞上CD11a。
Objective:To explore the effect of cyclophosphamide and colchicine on CD11a,CD11b,CD18 and CD54 in patients with acute ischemic stroke.Methods:84 patients within 72 hours after the onset of ischemic stroke were divided into treatment group(43 patients)and control group(41 patients).The control group was given general therapy.The cyclophosphamide 0.1～0.2g/d and the colchicine 1mg/d were given to the treatment group for 10 days besides the general therapy.CD11a,CD11b,CD18 and CD54 were determined before and after administration.Results:Compared with control group,the decrease in the expression of CD18 and CD54 in the treatment group was more obvious(P<0.05),but the expression of CD11a and CD11b was not significantly decreased(P>0.05).Conclusions:Combined therapy with cyclophosphamide and colchicine may reduce adhesion molecule CD18 and CD54 expression on leukocytes in patients with acute ischemic stroke,but no obvious effect of CD11a and CD11b on leukocytes was observed.
出处
《华西医学》
CAS
2003年第4期500-501,共2页
West China Medical Journal
