419例新生儿败血症血培养及药敏分析

The Blood Culture of 419 Neonates and Drug Sensitivity Assay

目的 了解新生儿败血症患者血培养细菌的分布及其对有关抗生素敏感和耐药情况。 方法 利用BACTEC 90 5 0血培养仪进行检测。 结果 419份血标本中分离出致病菌 5 5株 ,阳性率为 13 1% ,G+球菌 41株 ,占74 5 % ,其中以凝固酶阴性葡萄球菌分离率最高 ,占 5 4 5 % ,其中又以表皮葡萄球菌居首位。G-杆菌 8株占 14 5 % ,其它菌 6株占 11 0 %。凝固酶阴性葡萄球菌对青霉素高度耐药 ,敏感率最高的为万古霉素和泰能 ,其次为阿莫西林 /棒酸、头孢噻肟、头孢唑啉。 结论 凝固酶阴性葡萄球菌为新生儿败血症患者中常见的致病菌 ,阿莫西林 /棒酸、头孢噻肟、头孢唑啉疗效好 ,副作用少 。

Objective To study the distributions of strains in blood culture and their drug sensitivity in neonates who suffer from hematosepsis. Methods The blood samples were detected by blood culture analyzer BACTEC 9050. Result 55 of strains were isolated from the 419 blood samples and the rate was 13.1%. There are 41 strains of G + coccus in 55 of strains, which occupies 74.5%. Coagulase negative staphylococcus has the highest isolation rate, which ranks 54.5%, and epidermis staphylococcus ranks the first. 8 strains of G - bacilli were isolated and the rate was 14.5%, six strains of other bacteria 11%, respectively. Coagulase negative staphylococcus have a strong resistance to oxacillin and a high sensitivity to vancomycin and imipenem, then amoxicillin/clavulanic acid, cefetaxime and cefazoline. Conclusion Coagulase negative staphylococcus are the common bacteria which cause neonatal hematosepsis. Amoxicillin/clavulanic acid, cefetaxime and cefazoline have good effects on this disease with few side-effects, which can be selected with the first priority.