泌尿生殖道感染的葡萄球菌分布及对氟喹诺酮类药物的敏感性研究

The Distribution of Staphylococcus Infection in Urogenital Tract and Comparative in vitro Activity of Fluoroquinolone

目的 了解泌尿生殖道感染的葡萄球菌分布及对氟喹诺酮类药物的敏感性。 方法 选择 2 44例泌尿生殖道感染患者 ,对其葡萄球菌进行分离鉴定 ,用 6种氟喹诺酮类药物对分离到的葡萄球菌进行了敏感性试验。 结果 与泌尿生殖道感染有关的葡萄球菌分离率为 61.0 7% ,其中人葡萄球菌、金黄色葡萄球菌、溶血葡萄球菌较为常见。在 6种药物中加替沙星抗菌活性最强 ,随后依次为司帕沙星、左氧氟沙星、氧氟沙星、环丙沙星 ,诺氟沙星活性最差。 结论 人葡萄球菌、金黄色葡萄球菌、溶血葡萄球菌是泌尿生殖道感染的常见细菌 。

Objective To understand the distribution of staphylococcus in urogenty infection and staphylococcus sensitivity to fluoroquinolones. Methods Select 244 urogenty infectors,the staphylococci were cultured and identified.Minimal inhibitory concentrations(MIC)were measured by using agar dilution method. Result Among all samples,the isolation rate of staphylococcus was 60.07%,the isolation rates of staphylococcus hominis,staphylococcus aureus and staphylococcus haemolyticus were significantly higher than those of the other staphylococci.Among 6 fluoroquinolones,gatifloxacin was most active agent against staphylococci. Conclusion In urogenital tract,the infections of S.hominis,S.aureus and S.haemolyticus were more commonly seen than other staphylococci.The staphylococci have varying degree of resistance to commonly used fluoroquinolones.