TNF-α,IL-1β活性在结核性胸膜炎胸膜纤维化中的检测

The Activity of TNF-α,IL-1β Detected in TB Pleuritis Pleural Fibrosis

目的 研究和观察TNF -α ,IL -1β改变在结核胸膜炎胸膜纤维化中的临床意义。 方法 用放射免疫法对 5 2例结核性胸膜炎患者进行胸液TNF -α ,IL -1β检测。 结果 2 0例在治疗时已发生胸膜纤维化者 ,17例在治疗过程中后发的胸膜纤维化者 ,胸液TNF -α ,IL -1β明显较 15例在治疗过程中未出现明显胸膜纤维化者高 ,分别比较均有显著性差异 (P <0 0 1) ,而前两者比较无显著统计意义 (P >0 0 5 )。 结论 结核胸膜炎有胸膜纤维化者和将发生胸膜纤维化者均存在活跃的TNF -α ,IL -1β合成和分泌 ,高水平的TNF -α ,IL

Objective To investigate and observe the clinical significance of the alteration at TNF-α,IL-1β in TB pleuritis pleural fibrosis. Methods To detect chest fluid TNF-α,IL-1β in radio-immunization to 52 patients with TB pleuritis. Result For the 20 TB pleuritis who had had pleural fibrosis before treatment and the 17 cases who developed pleural fibrosis during treatment, their serum TNF-α and IL-1 β were obviously higher than that of those 15 cases who didn't develop pleural fibrosis during treatment. The difference is significant (P<0.01). While the comparison between the first two group is not significant (P>0.05). Conclusion TB pleuritis who are with or who are developing with pleural fibrosis both have synthesis, excretion activity of TNF-α,IL-1 β. High level of TNF-α,IL-1 β suggests that pleural fibrosis exists exspecially or is processing.