糖皮质激素对传染性非典型肺炎患者糖代谢的影响

Effect of glucocorticoid therapy upon glucose metabolism in SARS patients

目的 探讨糖皮质激素治疗对传染性非典型肺炎(SARS)患者糖代谢的影响。方法 将214例SARS患者分为激素组(H)和非激素组(NH);筛选与血糖水平有关的因素,进行多元回归分析。结果H组空腹血糖(FBG)显著高于NH组(P<0.001);H组中甲泼尼龙(M)、泼尼松(P)或两药混用(M+P)对FBG的影响有显著性差异(P<0.001),M>M+P>P;FBG水平与患者年龄、激素日均剂量存在正相关(P<0.001)。结论糖皮质激素治疗使SARS患者糖代谢受损。

Objective To study the effect of glucocorticoid therapy upon glucose metabolism in SARS patients. Methods SARS patients were divided into two groups,one was treated with glucocorticoid (Group H) ,another was con-trol (Group NH). The factors that are related to glucose were screened and analyzed with the way of multiple regression analysis. Results The levels of FBG was higher in H-group than in NH-group(P<0.001). In H-group, the effect of therapy upon FBG is significantly different among three groups: Methylprednisolone( M )、prednisone-group ( P ) and M + P-group(P<0.001),M>M+P>P;FBG was well positively correlated with age of the patients and the average dose of glucocorticoid used per day ( P < 0. 001). Conclusions The administration of glucocorticoid impaired glucose metabolism in SARS patients.