^(89)锶在老年骨转移癌止痛康复治疗中的意义

A study on ^(89)Strontium radionuclide therapy for pain-relief and rehabilitation of senile patients with bone metastatic cancer

目的 明确放射性核素89锶 ( 89Sr)对老年骨转移癌的止痛疗效、对骨转移灶影像学的影响以及患者在治疗中的耐受情况 ,评价其在老年骨转移癌止痛康复治疗中的意义。方法 观察 2 7例老年骨转移癌患者使用89Sr治疗后的止痛效果 ,比较治疗前、后骨转移灶的影像学变化 ,监测一般不良反应及血液学毒副反应。结果 止痛总有效率为 70 .4% ,来源于前列腺癌及乳腺癌的骨转移癌止痛有效率为 78.9%。治疗后部分患者转移灶消失或放射性浓聚变淡。副反应主要表现为对骨髓造血功能的轻度可逆性损害 ,而对肝、肾功能无明显不良影响。结论 89Sr是治疗老年骨转移癌疼痛的一种安全有效的方法 ,为老年骨转移癌止痛康复治疗提供了一种有益的新方法。

Objective To evaluate the efficacy and the toxicity of 89Strontium( 89 Sr) radionuclide therapy for the senile patients with bone metastatic cancer, and study the effects of 89 Sr on the image of bone metastasis, and to assess the utility of 89 Sr treatment for the senile patients in rehabilitation. Methods The effect on pain relief and the side effects of 27 senile patients with bone metastatic cancer were observed. The bone SPECT image was compared between those before and after the treatment, blood routine and blood biochemistry was tested. Results The total response rate was 70.4%, while the response rate of bone metastasis originated from prostatic cancer and breast cancer was 78.9%. A few metastasis sites in bone image disappeared or the concentration in the image became weak. A mild reversible harm to bone marrow function was the main side effect. 89 Sr had a little effect on blood biochemistry. Conclusion Radionuclide therapy with 89 Sr was an effective and well-tolerated method for the senile patients with bone metastatic cancer, which was a novel approach for pain-relief and rehabilitation of senile patients with bone metastatic cancer.