氧自由基损伤在老年轻度认知功能损害发病机制中的作用

The effect of free radical injury in the mechanism of senile mild cognitive impairment

目的 了解轻度认知功能损害(MCI)患者血清维生素E(Vit E)、超氧化物歧化酶(SOD)和丙二醛(MDA)的水平,探讨氧自由基损伤在老年轻度认知损害发病机制中的作用。方法 采用1:1配对病例对照设计,应用紫外分光光度法测定了45例老年MCI患者和45例健康老年人血清Vit E、SOD和MDA的含量,并进行分析。结果 老年MCI患者血清Vit E含量及SOD活性显著低于健康老年人(P<0.01),血清MDA含量显著高于健康老年人(P<0.01)。结论 氧自由基损伤参与了MCI的病理生理过程;临床上应给予外源性Vit E以进行早期干预治疗。

Objective To explore the clinical significance of serum vitamin E (Vit E), superoxide dismutase (SOD) and malondialde-hyde (MDA) in patients with mild cognitive impairment (MCI). Methods A paired design of 45 MCI and 45 healthy elderly ones was adopt-ed. The contents of serum vitamine E (Vit E), superoxide dismufase (SOD) and malondialdehyde (MDA) were assayed. Results The level ofserum Vit E and the activity of SOD in MCI were significantly lower than that of elder healthy controls (P<0. 01). The level of serum MDAin MCI was significantly higher than that of elder healthy subjects (P<0. 01). Conclusions Free radical injury was included in the patho-physiological process of MCI. The early intervention of Vit E should be given in MCI.