1[1]Natanson C. Anti-inflammatory therapies to treat sepsis and septic shock: a reassessment. Crit Care Med, 1997, 25:1 095
2[2]Abraham E. Therapies for sepsis emerging therapies for sepsis and septic shock. West J Med,1997, 166:195
3[3]Sands K, Bates D, Lanken P et al. Epidemiology of sepsis syndrome in 8 academic medical centers. JAMA, 1997, 278:234
4[4]Friedman G, Silva E, Vincent JL. Has the mortality of septic shock changed with time? Crit Care Med, 1998, 26:2 078
5[5]Natanson C, Esposito C, Banks S. The sirens' songs of confirmatory sepsis trials: Selection bias and sampling error. Crit Care Med, 1998, 26:1 927
6[6]Hack CE, Aarden LA, Thijs LG. Role of cytokines in sepsis. Adv Immunol, 1997, 66: 101
7[7]Bernard GR, Vincent JL, Laterre PF et al. Efficacy and safety of recombinant human activated protein C for treatment of patients with severe sepsis. N Engl J Med, 2001, 344:699
8[8]Abraham E. Why immunomodulatory therapies have not worked in sepsis. Intensive Care Med, 1999,25:558
9[9]Marcus AJ, Broekman MJ, Drosopoulos JH et al. The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39. J Clin Invest, 1997, 99:1 351
10[10]Gando S, Nanzaki S, Sasaki S et al. Activation of the extrinsic coagulation pathway in patients with severe sepsis and septic shock. Crit Care Med, 2000,26:2 005
3Martin GS,Mannino DM,Eaton S,et al.The epidemiology of sepsis in the united states from 1979 through 2000[J].N Engl J Med,2003,348(16):1 546-1 554.
4Brun-Buisson C,Doyon F,Carlet J,et al.Incidence,risk factors,and outcomes of severe sepsis and septic shock in adults:a multicenter prospective study in intensive care unit french ICU Group for severe sepsis[J].JAMA,1995,274(12):968-974.
5Villar J,Maca-Meyer N,Perez-Mendez L,et al.Bench to bedside review:understanding genetic predisposition to sepsis[J].Crit Care,2004,8(3):180-189.
6Baughman RP,Lower EE,Flessa HC,et al.Thromobocytopenia in the intensive care unit[J].Chest,1993,104(4):1 243-1 247.
7Keh D,Boehnke T,Weber-Cartens S,et al.Immunologic and hemodynamic effects of low-dose hydrocortisone in septic shock:a double-blind,randomized,placebo-controlled,crossover study[J].Am J Respir Crit Care Med,2003,167(4):512-520.
8Shua F,Kobayashia H,Fukadowe K,et al.Activated protein C suppresses tissue factor expression on U937 cells in the endothelial protein C receptor dependent manner[J].FEBS Lett,2000,477(3):208-212.
9Bernard GR,Vincent JL,Laterre PF,et al.Efficacy and safety of recombinant human activated protein C for severe sepsis[J].N Engl J Med,2001,344(10):699-709.
10Joyce DE,Gellbert L,Ciaccia A,et al.Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis[J].J Biol Chem,2001,27(6):199-203.
