特发性肺纤维化患者支气管肺泡灌洗液中细胞因子研究

Study on cytokines of bronchoalveolar lavage fluid in patients with idiopathic pulmonary fibrosis

目的 检测支气管肺泡灌洗液 (BALF)中转化生长因子β1 (TGF β1 )、血小板衍生生长因子 (PDGF)含量变化及细胞改变 ,探讨其临床应用价值。方法 用ELISA方法检测BALF中TGF β1 、PDGF含量。结果 特发性肺纤维化 (IPF)患者支气管肺泡灌洗液中TGF β1 、PDGF含量与对照组比较明显升高 (P <0 .0 1 ,P <0 .0 5 )。结论 TGF β1 、PDGF参与IPF的形成 ,检测BALF中TGF β1 、PDGF含量可作为IPF的辅助诊断指标及判断疾病活动的标志 ,对TGF β1、PDGF的生物活性进行阻断 ,将是治疗IPF一种有前途的方法。

Objective To measure the changes of contents of transforming growth factor beta1(TGF β 1)and platelet derived growth factor (PDGF) and the transformation of cells in bronchoalveolar lavage fluid(BALF),to discuss their clinic applied value.Methods The ELISA methods were used to measure the contents of TGF β 1,PDGF in BALF.Results In the BALF of patients with IPF,the contents of TGF β 1,PDGF were significantly increased than those in normal control subjects( P <0.01, P <0.05).Conclusion TGF β 1,PDGF involved in the formation of IPF are helpful in diagnosis of IPF and act as the markers of activity of disease;blocking the biologic activity of TGF β 1,PDGF may has a great future in treatment for IPF.