前列腺液中IL-4水平与慢性非细菌性前列腺炎的关系

The rleation between IL-4 level in expressed prostatic secretion and chronic abacterial prostatitis

目的 :分析前列腺液中白细胞介素 - 4(IL - 4)含量与前列腺炎症状之间是否具有相关关系 ,探讨前列腺炎时前列腺局部免疫反应的类型以及IL - 4在前列腺炎发病过程中的的作用。资料与方法 :泌尿外科门诊就诊的前列腺炎患者 ,以“两杯法”筛出慢性非细菌性前列腺炎患者 2 4名 ,正常人 16名 ,检验前列腺液常规后检测前列腺液中IL - 4的含量 ,同时依据美国国立卫生院前列腺炎症状指数评分表 (NIH -CPSI)进行评分 ,结果用SPSS软件统计分析。结果 :慢性非细菌性前列腺炎患者组IL - 4含量为 5 3.2 7± 6 0 .2 0pg/ml,NIH -CPSI评分 2 2 .13± 4 .4 8;对照组IL - 4含量为 35 .6 2± 2 2 .4 5pg/ml。结论 :患者组和对照组间前列腺液中IL - 4含量无明显统计学差异 ,IL - 4水平与前列腺炎症状间亦无相关关系。说明前列腺炎的局部免疫反应不是以体液免疫为主的 ,IL - 4在前列腺炎的发病过程中不起主导作用 ,其作用可能仅是细胞因子间网络样调节作用的一部分。

Objective: We analyzed the relationship between IL-4 level and symptoms of chronic pelvic pain syndrome, discusse the function of IL-4 in the process of prostatic inflammation.Material and methods: 24 men with CPPS seen in our urology clinic and 16 normal men joined our study .The patients varied from 19 to 32 years(mean:24), and were classified by premassage and postmassage test offered by Nickel J.C. Controls varied from 24 to 27 years(mean:26). EPS samples were collected by digital rectal examination. After routine test of EPS ,the remainder of EPS was stored at 20℃ until thawed for analysis. At the same time, NIH-CPSI was used to evaluate the state of CPPS. Enzyme-linked immunoadsordent assays (ELISA) were used to measured IL-4.All samples were assayed for IL-4. All data were statistically analyzed by software SPSS. Result: IL-4: patients: 53.27±60.20pg/ml(mean±Std deviation);control :35.62±22.45pg/ml(mean±Std deviation). NIH-CPSI: 22.13±4.48(mean±Std deviation). There was no significant difference of IL-4 in EPS between CPPS and normal, and no correlation between IL-4 level and symptoms (P>0.05).Conclusion:There is no significant difference of IL-4 between CPPS and controls, and no correlation between Il-4 and symptoms. It shows that: the local immunologic reaction is not humoral immunity. IL-4 has no leader function in the process of CPPS, and it's function maybe a little part of whole cytokine network.