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线粒体基因组与肿瘤的相关性研究进展 被引量：4

Advances in research on relationship between mitochondrial genome and tumor
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摘要 线粒体在细胞能量代谢 ,氧自由基生成和细胞凋亡中发挥重要作用。肿瘤细胞的线粒体功能障碍是其重要的特征之一。正常细胞线粒体在分子、生化、代谢和遗传水平上明显区别于癌细胞。本综述重点讨论线粒体DNA的损伤与突变在细胞癌变中的地位和可能的作用机制。 Mitochondria play important roles in cellular energy metabolism,free radical generation and apoptosis. Mitochondrial dysfunction is one of the most profound features of cancer cells. Several distinct differences between the mitochondria of normal cells and cancer cells have been observed at the molecular,biochemical,metabolic and genetic levels. In this article,we review the relationship between mitochondrial DNA (mtDNA) and carcinogenesis of cancer cells. The possible mechanisms are also discussed.
作者 刘晓红 朱明华
机构地区 第二军医大学附属长海医院病理科
出处 《中国癌症杂志》 CAS CSCD 2003年第6期587-590,共4页 China Oncology
基金 国家自然科学基金资助项目 (3 0 0 70 3 44 3 0 0 70 83 9)
关键词 线粒体DNA 肿瘤 突变 mitochondrial DNA tumor mutation
分类号 R730.2 [医药卫生—肿瘤]
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  • 1[1]Anderson S, Bankier AT, Barrell BG, et al. Sequence and organization of the human mitochondrial genome [ J ]. Nature,1981,290(5806) :457-465.
  • 2[2]Hochhauser D. Relevance of mitochondrial DNA in cancer [ J ].Lancet ,2000,356( 7 ): 181-182.
  • 3[3]Yaron Y, Orr-Ortreger A. New genetic principles [ J ]. Clin Obstet Gynecol,2002,45( 3 ): 593-604.
  • 4[4]Delsite R, Kachhap S, Anbazhagnn R, et al. Nuclear genes involved in mitochondrial-to-nucleus communication in breast cancer cells [J]. Mol Cancer,2002,1( 1 ): 6-18.
  • 5[5]Jannifer SC, Peng H. Mitochondrial defects in cancer [J]. Mol Cancer, 2002,1(1): 9-28.
  • 6[6]Loisean D, Chevrollier A, Douay O, et al. Oxygen consumption and expression of the adenine nucleotide translocator in cells lacking mitochondrial DNA [J]. Exp Cell Res,2002,278( 1 ):12-18.
  • 7[7]Allen RG, Balin AK. Oxidative influence on development and differention:an overview of a free radical theory of development [J]. Free Radical Biol Med, 1989,6 ( 6 ) :63 1-661.
  • 8[8]Santos JH, Hunakova L, Chen Y, et al. Cell sorting experiments link persistent mitochondrial DNA damage with loss of mitochondrial membrane potential and apoptotic cell death [J]. J Biol Chem ,2003 , 278(3) :1728-1734.
  • 9[9]Richter C, Park JW, Ames BN, et al. Normal oxidative damage to mitochondrial and nuclear is extensive [ J ]. Proc Natl Acad Sci USA, 1988,85( 17 ) :6465-6477.
  • 10[10]Polyak K, Li Y, Zhu H, et al. Somatic mutation of the mitochondrial genome in human colorectal tumours [ J ].Nat Genet, 1998,20( 3 ) :291-293.

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中国癌症杂志
2003年 第6期

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