1[1]Hoff PM,Ansari R,Batist G,et al.Comparison of oral capecitabine versus intravenous fiuorouracil plusleucovorin as first-line treatment in 605 patients with metastatic colorectal cancer:Results of a randomized phase Ⅲ study.J ClinOncol,2001,919:2282-92.
2[2]Becouarn Y,Ychou M,Ducreux M,et al.Phase Ⅱ trail of oxaliplatin ss first-line chemotherapy in metastatic cororectal cancer patients.J Clin Oncol,1998,16:2739-44.
3[3]Machover D,Diaz-Rubio E,Gramont A,et al.Two consecutive phase listudies Of oxaliplatin(L OHP)for tenement of patients with advanced coiorectal carcinoma who resistant to previous with fiuoropyrimidlnes.Ann Oncol,1996,7:95-8.
4[4]Shimdda Y,Yoshino M,Wakui A,et al.Phase Ⅱ study of CPT-11,a camptothecin derivative,in metastatic colorectal cancer.J ClinOncol,1993,11:909-913.
5[5]Rothenberg ML,Cox JV,Devore RF,et al.A multicenter phase Ⅱ trial of weekly irinotecan(CPT-11)in patients with previously treated colorectal caclnoma.Cancer,1999,85:786-95.
6[6]Cunningham D,Pyrhonen S,James RD,et al.Randomised trial of irinotecan plus supportive care versus supportive care alone after fiuorouracil failure for patients with metastatic colorectal cancer.Lancet,1998,352:1413-18.
7[7]Rougier P,Cutsem EV,Bajetta E,et al.Randomized trial of irinotecan versus fiuorouracil by continuous infusion after fiuorouracil failure in patients with metastatic colorectal cancer.Lancet,1998,352:1407-12.
8[8]Piedbois M.Modulation of 5-fluorouracil in patients with advanced colorectal cancer:evidence in terms of response rate.Advanced colorectal cancer meta-analysis project.J Clin Oncol,1992,10:896-903.
9[9]Moran RG.Leucovorin enhancement of the effects of the fiuoropyrimidines on thymldylate synthase.Cancer,1989,63:1008-12.
10[10]Moertel CG,Fleming TR,Macdonald JS,et al.Levamisole and flnorouracil for adjuvant therapy of resected colon carcinoma.New Engl J Med,1990,322:352-358.
