NF-κB在大鼠视网膜缺血再灌注损伤中的表达及意义

The Research on NF-KB Fxpression in Rat's Ischemia-reperfusion Injuried Retina

目的了解NF-κB在大鼠视网膜缺血再灌注损伤中的表达及意义。方法建立大鼠视网膜缺血再灌注模型,以SABC法检测NF-κB在视网膜中的表达,做统计学处理。结果 NF-κB在视网膜缺血再灌注后6h开始表达,第24h达到最高峰,48h开始表达减弱。结论 NF-κB在视网膜缺血再灌注损伤中起重要作用。

Purpose To study the NF-кB expression in rat's retina which was injuried by ischemia-reperfusion. Methods The model of rat's retina ischemia-reperfusion was built,and SABC method was used to test the NF-кB expression in rat's retina.Results At one hour after ischemia-reperfusion there was no NF-icB expressed in rat' s retina but after six hours of ischemia-reperfusion,there was some NF-кB experssed in retina, which became more and more,reached the hightest level at twenty four hours after ischemia-reperfusion and then began to decrease,but there was NF-кB expressed in retina after seventy-two hours.Conclusion NF-кB is very important in rat's retina ischemia-reperfusion injury.