摘要
目的研究人脑胶质瘤(HBG)与人脑转移瘤(HBMC)中核转录因子κBP65(NF-κBP65)的表达及其在肿瘤生物学行为中的作用。方法应用SABC方法进行免疫组织化学染色,观察6例正常人脑组织、18例HBG组织与12例HBMC组织中NF-κBP65的表达及与肿瘤生物学行为之间的关系。结果正常脑细胞中NF-κBP65仅微量表达,在HBG细胞与HBMC细胞中呈不同程度的表达;在高级别HBG、HBMC和复发型HBG中,表达水平较低级别HBG细胞的高(P<0.01)。结论NF-κBP65表达的增强与HBG和HBMC恶性程度的增高、肿瘤浸润关系密切,并在HBG的复发中起重要作用。
Objective To study the immunohistochemical changes of nuclear f actor-κBP65 (NF-κBp65) in human brain glioma (HBG) and human brain metastatic carcinoma (HBMC) and the role of NF-κBP65 in the biological behavior of the tu -mors. Methods The protein expression of NF-κBP65 were examined with SABC immun ohistochemical technique in 18 HBG, 12 HBMC and 6 normal brain tissue samples, and the correlation between the expression and the biological behavior of the t umors was analyzed. Results Normal brain tissues had only trace expression of NF -κBP65, whereas all tumor tissues ex-amined expressed NF-κBP65. The level of N F-κBP65 in high-grade HBG, HBMC and recurrent HBG tissues was consider-ably hig her than that in low-grade HBG tissues (P<0.01). Conclusion NF-κBP65 expression is associated with the malignant progression, invasion and angiogenesis of HBG and HBMC, and it may play a crucial role in the recurrence of HBG.
出处
《第一军医大学学报》
CSCD
北大核心
2004年第1期75-78,共4页
Journal of First Military Medical University
基金
山东省教委基金(99k53)~~
