黄芪水煎液抗Ⅰ型单纯疱疹病毒的实验研究

Experimental study of the effect of Astragalus membranaceus against herpes simplex virus type1

目的研究黄芪抗Ⅰ型单纯疱疹病毒(HSV-Ⅰ)的作用。方法在人胚肺二倍体细胞系统中,采用对病毒所致细胞病变的抑制实验,观察黄芪水煎液抗HSV-I的药效。结果黄芪水煎液的半数抑制浓度为0.98 μg/ml,最小有效浓度为1.95 μg/ml,治疗指数为128。结论黄芪有较显著的抗HSV-Ⅰ作用,且对细胞毒性低。

Objective To study the inhibitory eff ec ts of Astragalus membranaceus on herpes simplex virus type 1(HSV-1). Methods In the 2BS cells infected with HSV-1, the antiviral effect of Astragalus membranac eus decoction was investigated by observing the inhibition of HSV-1-induced cyt opathic effect in response to treatment with the decoction. Results The half in hibition concentration (IC50) and minimal inhibition concentration (MIC) of Astr agalus membranaceus were 0.98 and 1.95 μg/ml respectively, with the therapeutic index (TI) of 128. Conclusion Astragalus membranaceus has obvious HSV-1-inhibit -ing efficacy and low cytotoxicity.