2-(4-硝基苯基)乙醇的制备

Preparation of 2-(4-nitrophenyl)ethanol

用2-苯乙醇为原料,经乙酸酯化、混酸硝化、碱性水解得到2-(4-硝基苯基)乙醇,考察了混酸和酯化物的最佳投料比以及反应温度,利用邻、对位终产物的不同熔点确定了最佳结晶温度,总收率79.8％,对位产物含量98.6％。

2-(4-Nitrophenyl)ethanol was prepared by esterification of 2-phenylethanol with acetic acid, nitration with HMO3 and H2SO4, and then alkaline hydrolysis with an overall yield of 79.8% and 98.6% purity.