人类乳头状瘤病毒与声带息肉的关系

Relationship between Infection of Human Papilloma Virus and Vocal Cord Polyp

目的 :探讨声带息肉与人类乳头状瘤病毒(HPV)感染的关系。方法 :在光学显微镜下观察声带息肉组织切片中上皮单纯角化、角化不良、单纯增生、不典型增生和角化伴增生的形态学变化 ,以及挖空细胞在声带息肉组织中出现的情况。并应用免疫组织化学SABC -KIT方法进行HPV检测。结果 :声带息肉挖空细胞的出现与性别、上皮单纯角化、角化不良、单纯增生、不典型增生和角化伴增生无关 (均P>0.05) ;HPV感染与上皮单纯角化、角化不良、单纯增生、不典型增生及角化伴增生无关 (均P>0.05) ;而挖空细胞的出现与HPV的感染有关 (P<0.01)。结论 :在声带息肉的发生发展中HPV起着重要作用。

Objective:To evaluate the relationship between infection of human papilloma virus(HPV)and vocal cord polyp.Methods:The morphological changes and koilocytosis were observed in the tissue slices of vocal cord polyp.Results:There was no relationship between koilocytosis or infection of HPV and epithelial simple keratosis,dyskeratosis,simple proliferation,atypical proliferation and keratosis with proliferation(all P>0.05),but there was a significant relationship between koilocytosis and infection of HPV(P<0.01).Concluˉsion:The HPV may play an important role in the develoment of VCP.