A型肉毒素局部注射治疗面部肌张力障碍——附73例报告

Management for facial muscle dystonia with botulinum toxin type a local injection

目的 探讨面部肌张力障碍的临床治疗。方法 对A型肉毒素 (BTXA)治疗的 73例面部肌张力障碍的患者进行回顾性研究。结果 BTXA治疗后病情的好转是显著的 (P <0 .0 1) ,可重复治疗 ,并再次取得疗效。 5例患者配合口服药治疗。结论 BTXA局部肌肉注射是治疗面部肌张力障碍的一种安全、有效的治疗方法 ,对于注射BTXA后症状缓解持续时间短及受累肌肉较多、BTXA治疗难度大的患者可采用注射BTXA与口服抗胆碱药 (安坦 )、中枢作用肌松剂 (脊舒 )、多巴胺受体拮抗剂 (泰必利 )相结合的方法。

Objective To explore the clinical remedy of facial muscle dystonia.Methods A retrospective research was done on 73 cases.Results It was very significantimprovement pre-treatment and post-treatment(P<0.01). Repeated the injection could reappear the therapeutical effect. Five patients′ therapy combine oral drug.Conclusion Botulinum toxin type A(BTXA) local injection is a safe, effective, simple and easy means for the treatment of facial muscle dystonia. The patients whose symptom lasted shorter after injection BTXA and reference muscles are too extensive to treat difficultly can combine injection BTXA with oral drug (artane,spinax,tiapride).