异体软组织修复材料在口腔颌面部缺损中的应用

A clinical study on the repair of oral mucous membrane defect with homologous acellular dermal matrix

目的 探讨异体软组织修复材料 (异体脱细胞真皮基位 )在口腔颌面外科应用的可行性。方法 选择口腔粘膜组织缺损患者 4 6例 ,在创面上采用异体脱细胞真皮基质覆盖 ,并对修复后创面情况和组织病理进行观察。结果 所有口腔粘膜创面愈合良好 ,无 1例出现排斥反应。经 4～ 6月后组织学观察 ,异体脱细胞真皮基质处所生成的组织与正常粘膜组织不易区分。结论 异体脱细胞真皮基质可以作为口腔粘膜缺损的修复材料推广使用。

Objective To investigate the feasibility of the transplantation of homologous acellular dermal matrix in oral mucous wound.Methods Forty-six patients with oral soft tissue wound were selected.The wound was covered with homologous acellular dermal matrix.The survival rates and histological changes were observed.Results All the wounds grafted healed very well without any suppuration,bleeding or infection under the grafted mucous membrane.No obvious immune rejection was seen.The survival rate of the homologous acellular dermal matrix was 95.40% .No difference was found between mucous epithelium and graft epithelium for 4～6 months.Conclusion This kind of homology acelluar dermal matrix can be widely used to cover oral mucous soft tissue wound.