乳腺癌患者血清中肿瘤相关物质群的水平

The level of serum tumor supplies group of factors in patients with breast carcinoma

目的 探讨乳腺癌患者血清TSGF水平及其临床意义。方法 用光电比色法检测 2 0 0例乳腺癌患者及健康对照 6 6人的血清TSGF水平。结果 初治、治疗无效及复发转移患者的血清TSGF水平分别为 (6 7.5± 4 .9)U/ml、(6 7.5± 4 .7)U/ml及 (6 5 .5± 9.6 )U/ml,均明显高于治疗显效组的 (5 5 .9±5 .1)U/ml及对照组的 (5 5 .5± 5 .3)U/ml(P <0 .0 1) ;局部复发、转移者血清TSGF水平分别为 (6 5 .0±9.8)U/ml、(6 6 .2± 9.1)U/ml,其差异无统计学意义 (P >0 .0 5 ) ;以 6 4U/ml为阳性阈值 ,TSGF检测乳腺癌的灵敏度及特异度分别为 6 0 .3%、98.5 %。结论 检测血清TSGF水平对乳腺癌的疗效及预后判断有良好效果。

Objective To detect the clinical significance of serum tumor supplies group of factors(TSGF) in patients with breast carcinoma. Methods The serum TSGF level was measured by spectrophotometry in 66 healthy controls and 200 patients with breast carcinoma. Results The TSGF levels ( ±s ) were( 67.5 ± 4.9 )U/ml for initiated tumors, ( 67.5 ± 4.7 )U/ml for nonresponders and ( 65.5 ± 9.6 )U/ml for relapsed or metastases,and were profoundly higher than that in responders [( 55.9 ± 5.1 )U/ml] and controls [( 55.5 ± 5.3 )U/ml] ( P < 0.01 ), respectively. TSGF level is not obvious difference between locaregion recurrence and metastases [( 65.0 ± 9.8 )U/ml vs. ( 66.2 ± 9.1 )U/ml] ( P > 0.05 ). At the threshold of 64U/ml, TSGF assay indicated breast carcinoma with a specificity of 98.5% and a sensitivity of 60.3% . Conclusion The determination of TSGF might be a useful parameter for assessing of response to treatment and predicting prognosis of breast carcinoma.