高原犬自身胆汁灌注胰管致急性胰腺炎的病理观察

Pathologic observation of acute pancreatitis caused by autobile perfusion into pancreatic duct in dogs at high altitude

目的 :探讨犬自身胆汁以不同压力、不同持续时间灌注 2h,C组 4 0kPa灌注 6h胰管致高原犬急性胰腺炎早期胰腺的病理改变。方法 :将本地健康成年杂种犬 30只 ,随机分为 5组 ,每组 6只 ,以不同压力、不同持续时间将自身胆汁灌注入胰管 ,观察胰腺的病理改变。结果 :胆汁灌注的压力越大 ,持续时间越长 ,越容易引发急性出血坏死性胰腺炎 ;早期即有胰腺微循环障碍发生。结论 :胆汁灌注的压力。

Objective:To study the early pathologic changes of pancreas caused by autobile perfusion into dog's pancreatic duct with different duration at high altitude.Methods:Thirty healthy adult mongrel dogs were randomly divided into 5 groups.Autobile was perfused into dog's pancreatic duct with different pressure and duration to observe early pathologic changes of the pancreas.Results:The higher the perfusion pressure was or the longer the duration was,the easier it was to cause acute hemorrhagic necrotizing pancreatitis.Pancreatic microcirculatory disturbance was observed at early stage.Conclusion:There are significant influences of autobile perfusion pressure and duration,and pancreatic microcirculatory disturbance on the severity of acute pancreatitis at high altitude.