心绞痛患者治疗前后血浆中IL-2、TGF-β水平的变化

Changes of levels of interleukin 2 and transforming growth factor beta in plasma of patients with coronary spastic angina after and before treated

目的了解心绞痛(CSA)发病与IL-2、TGF-β的关系。方法 利用双抗体夹心酶联免疫吸附法(ELISA)检测20例心绞痛患者治疗前后血浆中白细胞介素-2(IL-2)、转化生长因子-β(TGF-β)含量的变化,并与正常对照组31例进行比较。结果 心绞痛患者治疗前后血浆中IL-2含量差异有显著性(P<0.05),治疗前明显高于治疗后;心绞痛患者血浆中IL-2含量明显高于正常对照组(P<0.001),而TGF-β含量明显低于正常对照组(P<0.01),治疗前后差异有显著性(P<0.05);不稳定型心绞痛(UA)与稳定型心绞痛(SA)患者血浆中IL-2和TGF-β含量差异均有非常显著性(P<0.001,P<0.01)。结论 IL-2、TGF-β与心绞痛发病过程密切相关。

Objective For learning the interrelationship between the pathogenesis of coronary spastic angina (CSA)and interleukin 2, transforming growth factor beta . Method To measuring the levels of interleukin 2(IL-2) and transforming growth factor beta (TGF-β)in plasma of 20 patients with coronary spastic angina after and before treated by ELISA method And IL-2 and TGF-βwere measured in 31 healthy controls. Result The levels of IL-2 in plasma of patients with coronary spastic angina were higher than health person (P<0. 001). There were different in patients after and before treated (P< 0. 05). Whereas the TGF-βwere decreased in patients (P<0. 01). And the levels of TGF-β in serum from patients after and before treated were different (P<0. 05). IL-2 and TGF-βin UA were significant different from in SA(P<0. 001,P<0. 01). Conclusion The results suggested that the IL-2 and TGF-β were related to the pathogenesis of coronary spastic angina .