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谷氨酸脱羧酶基因疫苗与1型糖尿病 被引量：1

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摘要 研究发现谷氨酸脱羧酶(GAD)与1型糖尿病(T1DM)关系密切,含相关载体、免疫佐剂的GAD基因疫苗能有效减轻胰岛炎、预防或延缓T1DM的发生。其机理与GAD基因疫苗在体内产生GAD,诱导T细胞向Th2细胞分化以及T细胞的Fas表达上调引起T细胞凋亡有关。
作者 罗建华 周智广
机构地区 中南大学湘雅二医院代谢内分泌研究所
出处 《国外医学（内分泌学分册）》 2004年第1期33-35,共3页 Foreign Medical Sciences(Section of Endocrinology)
基金 国家自然科学基金(NSFC30170440)
关键词 谷氨酸脱羧酶 基因疫苗 1型糖尿病 T细胞 导入方法 影响因素
分类号 R587.1 [医药卫生—内分泌] R394 [医药卫生—医学遗传学]
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参考文献17

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同被引文献21

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国外医学（内分泌学分册）
2004年 第1期

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