期刊文献+

糖尿病胰岛移植及细胞治疗的细胞来源 被引量:5

下载PDF
导出
摘要 胰岛移植或细胞治疗是根治1型糖尿病较为理想的方法,但同时也面临着供体匮乏的难题。近年来研究显示,除同种自体或异体胰岛外,异种胰岛尤其是选择猪供胰成为众多学者关注的焦点;另外对扩增胰腺β细胞及制造胰岛素分泌细胞株的研究亦取得了一定的成果;而干细胞工程及转基因技术的应用,使利用干细胞治疗糖尿病及人工构建类胰岛细胞成为可能。
作者 崔岱 刘超
出处 《国外医学(内分泌学分册)》 2004年第1期36-38,共3页 Foreign Medical Sciences(Section of Endocrinology)
基金 江苏省政府医学重点学科项目基金[苏卫科教(2001)34]
  • 相关文献

参考文献14

  • 1Trivedi N, Hollister Lock J, Lopez-Avalos M D, et al. Increase in betacell mass in transplanted porcine neonatal pancreatic cell clusters is due to proliferation of beta-cells and differentiation of duct cells. Endocrinology ,2001, 142:2115-2122.
  • 2Zulewski H, Abraham E J, Gerlach M J, et al. Multipotential nestin positive stem cells isolated from adult pancreatic islets differentiate exvivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes, 2001,50: 521-533.
  • 3Macfarlane W M, Cragg H, Docherty H M, et al. Impaired expression of transcription factor IUF1 in a pancreatic β-cell line derived from a patient with resistent hyperinsulinaemic hypoglycaemia of infancy ( nesidioblastosis). FEBS Lett, 1997,413: 304-308.
  • 4Vasir B, Reitz P, Xu G, et al. Effects of diabetes and hypoxia on gene markers of angiogenesis(HGF, cMET, uPA and uPAR, TGF-α, TGFβ, bFGF and Vimentin) in cultured and transplanted rat islets. Diabetologia, 2000,43: 763-768.
  • 5Shapiro A M J, Lakey J R T, Ryan E A, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. New Engl J Med,2000,343:230-238.
  • 6Robbins P D, Tahara H, Ghivizzani S C. Viral vectors for gene therapy. Trends Biotechnol, 1998,16:35-40.
  • 7Lee H C, Kim S J, Kim K S, et al. Remission of type 1 diabetes by gene therapy using a single chain insulin analogue. Nature, 2000,408:483-488.
  • 8Yoshida S, Kajimoto Y, Yasuda T, et al. PDX-1 induces differentiation of intestinal epithelioid IEC-6 into insulin-producing cells. Diabetes,2002, 51:2505-2513.
  • 9Cheung A T. Glucose dependent insulin release from genetically engineered K cells. Science,2000,290:1959-1962.
  • 10Weir G C, Bonner-Weir S. Scientific and political impediments to successful islet transplantation. Diabetes, 1997,46:1247-1256.

同被引文献69

引证文献5

二级引证文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部