内毒素检测在内毒素血症治疗中的研究进展

Progress of Endotoxin Determination in Endotoxaemia

内毒素是造成内毒素血症(endotoxaemia)、多器官功能衰竭(multipleorgandysfunctionsyndrome,MODS)等病症的关键刺激物,一些非典型肺炎可能死于“急性内毒素中毒”,快速、可靠、灵敏地检测病人血液中内毒素的含量对于治疗内毒素血症及其并发症具有很重要的意义。本文重点回顾了内毒素检测方法的发展和应用,最后对其应用和发展趋势进行了简要的展望。

Endotoxin is the most powerful stimulus which causes clinical syndromes known as sepsis and Multiple Organ Dysfunction Syndrome (MODS).Even some people with SARS died because of a high level of endotoxin in blood.A rapid,reliable,and sensitive detection for endotoxin is very important for treatment of endotoxaemia and its relative diseases.The application and development of endotoxin detection are overviewed.Future directions for biosensors development and problems are discussed in the final part of this review.