大脑胶质瘤病的外科治疗

Surgical treatment of gliomatosis cerebri

目的 :探讨大脑胶质瘤病 (GC)的诊断方法和疗效。 方法 :对该科 1993年至 2 0 0 3年收治的 6例GC患者 ,对其临床及影像学表现进行分析 ,并采用手术治疗 ,术后行放疗或化疗。 结果 :6例患者死亡 5例 ,从首发症状起平均病程 16 .4 (6～ 2 3)个月 ,有 1例患者病程为 5个月 ,仍在随访中。 结论 :GC有特殊的MR表现 ,该病预后较差。

Objective:To discuss the diagnosis, treatment and outcome of patients with gliomatosis cerebri (GC). Methods:Retrospectively reviewed the clinical manifestations and radiological appearances of 6 patients with GC, which were diagnosed in our hospital between 1993 and 2003. We employed surgical treatment in three patients, stereotactic biopsy in two, and the other one received both biopsy and surgery. Results: The lesions of GC infiltrated more than two lobes in brain. CT studies showed diffuse hypodensity changes and enhancement was absent in four patients. MRI examinations revealed isointense or hypointense regions on T1WI, and uniformly high signal on T2WI. MRI also disclosed structural enlargement. All patients received radiotherapy after surgery and three patients underwent chemotherapy additionally. Five patients died during follow up with average course of 16.4 months. Conclusion:MRI examination is valuable in the diagnosis and the prognosis of GC is poor.