外照射联合腔内后装治疗T_1、T_2期鼻咽癌的疗效观察

Effect of External Beam Radiotherapy Combined with Intracavitary Brachytherapy in the Treatment of Patients with Stage T_1 and T_2 NPC

目的 探讨鼻咽癌外照射后期联合高剂量率腔内后装治疗的效果及并发症。方法 有计划地对首程T1 、T2 期鼻咽癌患者 5 2例 ,分为单纯外照射组 ( 2 6例 )和外照射联合高剂率腔内后装推量组 (综合放疗组 2 6例 ) ,其中综合放疗组在鼻咽癌外照射至DT40Gy、5 0Gy、60Gy时行腔内后装治疗一次。结果 综合放疗组与单纯放疗组的三年肿瘤局部控制率分别是 10 0 %与 73 0 8%,两组有显著性差异 ( P <0 0 1) ;3年生存率是 92 3 1%和 84 61%,无明显差异 ( P <0 0 5 )。结论 T1 、T2 期鼻咽癌外照射后期联合高剂量率腔内后装治疗能提高肿瘤局部控制率 ,减少外照射的剂量及降低其并发症的产生。

Objective To study the therapeutic effect and complication of external beam radiotherapy (EBR) plus intracavitary brachytherapy (IB) on nasopharyngeal carcinoma(NPC). Methods 52 patients with stage T 1,T 2 NPC were divided into two groups, 26 patients treated by EBR and the other 26 patients treated by EBR plus IB (combined radiotherapy group). IB was given to the patients of combined radiotherapy group when the external radiotherapy dose amounted to 40Gy,50Gy and 60Gy, respectively. Results The 3-year local control rates of combined radiotherapy group and EBR group were 100% and 73.08%, respectively (P<0.01). The 3-year survival rates of them were 92.31% and 84.61% respectively (P>0.05). Conclusions External beam radiotherapy combined with intacavitary brachytherapy for stage T 1, T 2 NPC may rise the local control rates, and reduce the exteral beam radiation dose and the complication.