调脂治疗对高血压病患者颈动脉粥样硬化及合并脑卒中的干预

Lipid Lowing Intervention of Carotid Arteriosclerosis and stroke in Hypertension

为探讨在降压治疗的同时调脂对高血压病患者颈动脉粥样硬化及合并脑卒中的干预作用。对 10 2例高血压病患者应用微粒化非诺贝特进行为期 2 4个月的调脂干预并与 10 5例患者对照 ,观察干预前后患者颈动脉超声及血脂等指标的变化。结果发现 ,干预组调脂 2 4个月后颈动脉内膜中膜厚度基本保持稳定 ,内膜中膜厚度 内径比率及颈动脉斑块发生率均比调脂前有明显降低 (P <0 .0 5 ) ;与对照组相比 ,干预组脑卒中的相对危险性降低 34%。提示在有效降压治疗的同时加用调脂 ,对高血压病患者延缓颈动脉粥样硬化的进展和降低患者脑卒中的发生有良好的干预作用。

Aim To investigate the intervenient efficacy of lipid lowing therapy as well as blood pressure controling in carotid arteriosclerosis and stroke of patients with hypertension. Methods The carotid artery colordopler ultrasonography was examed and the levels of serum lipids were measured in 102 cases of hypertension using the Micronised Ferofibrate compared with 105 controls during 24 monthes. Results The intima-media thickness (IMT) of carotid artery was almost unchanged in lipid lowing intervention group after this period of treatment. The IMT/D ratio and the incidence of carotid arteriosclerosis plaque were reduced signifficantly after the therapy.The relative risk of stroke in intervention group was lowered by 34% compared with the controls. Conclusion The carotid arteriosclerosis and the stroke in hypertension could be well prevented with lipid lowing therapy while the patient's blood pressure had been controled.