广西老年糖尿病患者血清甘油三酯与高密度脂蛋白胆固醇比值与大血管并发症

The Study of Association between the Ratio of Fasting Blood Triglyceride to High Density Lipoprotein Cholesterol and Macrovascular Complications in Aged Type 2 Diabetes in Guangxi

为了探讨广西老年 2型糖尿病患者空腹血清甘油三酯与高密度脂蛋白胆固醇比值与大血管并发症患病率的关系。按中华医学会糖尿病学分会糖尿病慢性并发症调查统一项目进行 ,对广西 5 5 1例 6 0岁以上的老年 2型糖尿病患者血糖、血脂、血压和体重指数等指标进行综合研究。结果发现 ,高血清甘油三酯 高密度脂蛋白胆固醇比值组 (R >1.33)人群的血糖、舒张压、总胆固醇和体重指数高于正常血清甘油三酯 高密度脂蛋白胆固醇比值组(P <0 .0 5 ) ,其大血管并发症患病率也高于正常血清甘油三酯 高密度脂蛋白胆固醇比值组 (P <0 .0 5 )。单因素直线相关分析提示 :血糖、总胆固醇、低密度脂蛋白胆固醇、糖尿病病程、体重指数等因素与血清甘油三酯 高密度脂蛋白胆固醇比值水平呈正相关关系 (P <0 .0 5 ) ;多因素逐步回归法提示影响血清甘油三酯 高密度脂蛋白胆固醇比值的主要因素有空腹血糖、总胆固醇、低密度脂蛋白胆固醇、糖尿病病程及体重指数 (P <0 .0 5 )。结果提示 ,血脂代谢紊乱与老年 2型糖尿病大血管并发症发生有关 ,空腹血清甘油三酯 高密度脂蛋白胆固醇比值是反映 2型糖尿病血管并发症发生的一个可靠的指标。

Aim To study the association between the ratio of fasting blood triglyceride to high density lipoprotein cholesterol (TG/HDLC) and macrovascular complications in aged type 2 diabetes in Guangxi. Methods To investigate some marks such as fasting blood glucose (FBG), posty prandial blood glucose (PBG), fasting TG, HDLC, low density lipoprotein cholesterol (LDLC), TC, blood pressure (BP) and body mass index (BMI) of 551 above-60-aged type 2 diabetes in the survey of chronic complications of The Diabetes Society of Chinese Medical Association. Results PBG, SBP, TC and BMI of high TG/HDLC ratio group (R>1.33) is significantly higher than that of normal TG/HDLC ratio group (P<0.05); So does the prevalence rate of macrovascular complications (P<0.05); single-factor linear correlation analysis show that FBG, PBG, TC, LDLC, duration of DM and BMI, etc have positive correlation with TG/HDLC ratio (P<0.05); Multiple factor stepwise regression analysis show that the main factors affecting TG/HDLC ratio are FBG, TC, LDLC, BMI and duration of DM (P<0.05). Conclusion Dyslipidosis has association with the prevalence rate of macrovascular complications in aged type 2 diabetes. TG/HDLC ratio can indicate reliably the occurrence of macrovascular complications.