急性冠状动脉综合征患者血清中可溶性L-选择素的变化规律

Serum levels of soluble L-selectin in patients with acute coronary syndromes

目的 :观察急性冠状动脉综合征 (ACS)不同分型患者血清中可溶性L 选择素 (sL selectin)水平的变化规律及心肌梗死 (MI)患者sL selectin水平与肌酸激酶 同工酶 (CK MB)和MI面积的相关性。方法 :将 5 9例冠心病患者分为 3组 :急性MI组 2 6例 ,不稳定型心绞痛 (UAP)组 18例 ,稳定型心绞痛 (SAP)组 15例 ;另设正常对照组 19例。血清sL selectin水平应用ELISA方法测定 ;预测MI面积应用Michelle等公式。结果 :①SAP组血清sL selectin水平为 (0 .84± 0 .12 )mg/L ,明显低于正常对照组 (1.0 5± 0 .18)mg/L ,P <0 .0 5 ;②UAP组和急性MI组sL selectin测定值分别为 (1.0 9± 0 .19)、(1.4 0± 0 .6 4 )mg/L ,与SAP组相比明显增高 (P <0 .0 5 ) ;③sL se lectin与CK MB无相关性 ,与MI面积亦无相关性。结论 :sL selectin与ACS的发生发展密切相关 ,sL

Objectives: ① To investigate the of levels of soluble L-selectin (sL-selectin) in patients with acute coronary syndromes. ②To investigate the relationship among between the levels sL-selectin,CK-MB and the size of myocardial infarction. Methods:Serum concentrations of sL-selectin were measured by enzymelinked immunosorbent assay. The size of myocardial infarction was measure by ECG. Results:Serum levels of sL-selectin were lower (P< 0.05) in patients with stable angina [( 0.84± 0.12)mg/L] compared with those in subjects in the control group [ ( 1.05± 0.18) mg/L]. But the levels were increased (P< 0.05) in patients with unstable angina [( 1.09± 0.19 )mg/L] or acute myocardial infarction [( 1.40± 0.64) mg/L] compared with stable angina. There was no correlation between sL-selectin and CK-MB or the size of myocardial infarction. Conclusions: It shows that sL-selectin might contribute to the development of coronary heart disease . The level of sL-selectin can not express the size of myocardia infarction measured by ECG.