2[1]Otani K, Nita I, Macaulay W, et al. Suppression of antigen induced arthritis in rabbits by ex vivo gene therapy. J Immunol, 1996,156(9):3358-3562
3[2]Wehling P, Schulitz KP, Robbins PD, et al. Transfer of genes to chondrocytic cells of the lumbar spine: Proposal for a treatment strategy of spinal disorders by local gene therapy. Spine, 1997,22( 10):1092-1097
4[3]Apparailly F, Verwaerde C, Jacquetc, et al. Adenovirus mediated transfer of viral IL-10 gene inhibits murine collagen induced arthritis. J Immunol,1998,160(11) :5213-5220
5[4]Eskdale J, McNichou J, Wordsworth P, et al. Interleukin-l0 microsatilite polymorphisms and IL-10 locus alleles in rhemnatoid arthritis. Susceptibility [letter]. Lancet, 1998,352(9136): 1282-1283
6[5]Whalen JD, Leehman EL, Carlos CA, et al. Adenoviral transfer of the viral IL-10 gene periarticularly to mouse paws suppresses development of collagen induced arthritis in both injected and uninjected paws. J Immunol,1999,162(6): 3625-3632
7[6]Tsokos GC, Nepom TG. Gene therapy in treatment of autoimmune diseases.J Clin Invest,2000,106(2): 181-183
8[7]Kitajima I, Hanyu N, Kawahara K, et al. Ribozyme based gene cleavage approach to chronic arthritis associated with human T cell leukemia virus type I: Induction of apoptosis in synoviocytes by ablation of HTLV-I tax protein.Arthritis Rheum, 1997,40(12) :2118-2127
9Smolen JS,Kalden JR,Scott DI,et al.Efficacy and safety of leflunomide compared with placebo and sulphsalazine in active rheumatoid arthritis: a doubleblind, randomised, multicentre trial[].The Lancet.1999
10Fox RI.Mechanism of action of leflunomide in rheumatoid arthritis[].Journal of Rheumatology The.1998
