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基于非参数方法的肿瘤基因表达数据挖掘 被引量:3

Data Mining for Tumor Gene Expression Profiles Using a Nonparametric Method
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摘要 该文提出了一种基于非参数统计的模式识别方法,此方法并不对微阵列数据作总体分布假设,从而降低了噪声对预测结果的影响.该方法可适用于两总体及多总体的模式识别问题.通过对两个真实的肿瘤基因表达数据的分析,验证了方法的识别效果. This paper presents a pattern recognition model based on a nonparametric method. The method does not rely on any specific distribution of the microarray data, so it can reduce the influence of noise on classification results. It is applicable to two-class and multi-class pattern recognition. The proposed method has been applied to two sets of real microarray data of various human tumor samples to verify the effectiveness.
机构地区 上海大学理学院
出处 《上海大学学报(自然科学版)》 CAS CSCD 2003年第6期543-548,共6页 Journal of Shanghai University:Natural Science Edition
基金 国家 86 3高技术研究发展计划 (2 0 0 2 AA2 3 40 2 1 )资助项目
关键词 微阵列 非参数检验 非参数判别 模式识别 肿瘤 基因表达 数据挖掘 噪声 分子生物学 microarray nonparametric test nonparametric discriminant pattern recognition
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参考文献5

  • 1Nguyen Danh V, Rocke David M. Tumor classification by partial least squares using microarray gene expression data [J]Bioinformatics, 2002, 18(1): 39- 50.
  • 2Nguyen Danh V, Rocke David M. Multi-class cancer classification via partial least squares with gene expression profiles [J].Bioinformatics, 2002, 18(9) :1216-1226.
  • 3Alon U, Barkai N, Notterman D A, et al. Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays [J]. Proc Natl Acad Sci, 1999,96: 6745 - 6750.
  • 4Golub T R, Slonim D K, Tamayo P, et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring [ J ].Science, 1999, 286:531-537.
  • 5Kahn Javed, Wei Jun S, Ringnér Markus, et al.Classification and diagnostic prediction of cancer using gene expression profiling and artificial neural networks [J]. Nature Medicine, 2001, 7 (6): 673-679.

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