综合疗法对海洛因依赖患者复吸的影响

The Effect of Comprehensive Treatment on Controlling Relapse of Heroin Addicts

目的:观察海洛因依赖患者在住院过程中进行综合性治疗(美沙酮递减脱瘾、生物体适应性平衡调整、心理干预、纳曲酮的应用)对出院后复吸的影口向。方法:将海洛因依赖患者90例,按随机化方法分为综合治疗组、美沙酮纳曲酮组及单纯美沙酮治疗组各30例。观察三种治疗方案临床疗效及出院后半年复吸率。结果:综合治疗方案及美沙酮纳曲酮治疗方案在控制脱毒后稽延性戒断症状,缓解焦虑情绪、改善睡眠及降低心理渴求方面均优于单纯美沙酮脱瘾治疗(P<0.01),且出院后半年操守人数亦有显著差异(P<0.01)。综合治疗组半年复吸率降低66.67%。综合治疗方案的临床疗效及防复吸效果又优于美沙酮纳曲酮组(P<0.05)。结论:综合治疗方案临床操作简单易行,临床疗效显著,对海洛因依赖患者脱毒出院后的复吸起到积极预防作用,值得推广。

Objective:To assess the effect of comprehensive treatment (methadone mainten ance treatment + biological adjustment+ psychological interference+ naltrexone) on controlling relapse of heroin addicts after they left hospital. Methods:90 cases with heroin addiction were randomly assigned to comprehensive treatment gr oup (30 cases,group 1); naltrexone +methadone group (30 cases, group 2);pur e methadone maintenance treatment group (30 cases,group 3) respectively.Thes e groups were observed to compare their clinical curative effect and the relaps e rate of half a year after leaving hospital. Results:The effect of group 1 was better than group 3 in controlling protracted abstinence, r elieving anxiety, improving sleep, reducing psychological desire and had a dramatical difference (P<0.01).As to the relapse rate of half a year in gro up 1 it was reduced to 66.7%. The clinical curative effect and the effect on pr evention of relapse of group 1 were better than group 2 (P<0.05). Conclusion:Com prehensive treatment might be simple and effective . It could prevent heroin add icts from relapse. So it's worth spreading.